Coordinated Metabolism of Alcadein and Amyloid -Protein Precursor Regulates FE65-dependent Gene Transactivation*□S

From the ‡Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-ku Kita-12 Nishi-6, Sapporo 060-0812, Japan, the §Graduate School of Pharmaceutical Sciences, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan, the ¶Neurology Unit, Molecular Neuroscience Research Center, Shiga University of Medical Science, Seta, Otsu, Shiga 520-2192, Japan, the Department of Dementia Research, National Institute for Longevity Science, 36-3, Gengo, Morioka, Obu, Aichi 474-8522, Japan, the **Laboratory for Cell Asymmetry, Center for Developmental Biology, RIKEN, 2-2-3 Minatojima Minatomachi, Chuo-ku, Kobe 650-0047, Japan, the ‡‡Neuronal Cell Biology Laboratory, K. U. Leuven and Flanders Interuniversitary Institute for Biotechnology, Herestraat 49, B-3000 Leuven, Belgium, and the §§Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwanoha 5-1-5, Kashiwa, Chiba 277-8562, Japan